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On 9 June AD 68, Nero drove a dagger into his own throat in a freedman's villa outside Rome. He was the last of the Julio-Claudians, and his death opened the first succession crisis in imperial history - the Year of the Four Emperors.
On 11 February 55 AD, Britannicus — the biological son of Emperor Claudius — collapsed at a dinner party and died. He was thirteen years old, one day short of manhood. The poisoning that killed him was not an aberration. It was how the Julio-Claudian dynasty did business.